11 USC players were selected in the NFL draft — the most of any school.
- Reggie Bush – 2nd overall to New Orleans
- Matt Leinart – 10th overall to Arizona
- Winston Justice – 39th overall to Philadelphia
- Deuce Lutui – 41st overall to Arizona
- LenDale White – 45th overall to Tennessee
- Frostee Rucker – 91st overall to Cincinnati
- Dominique Byrd – 93rd overall to St. Louis
- Darnell Bing – 101st overall to Oakland
- David Kirtman – 163rd overall to Seattle
- LaJuan Ramsey – 204th overall to Philadelphia
- Fred Matua – 217th overall to Detroit

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